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In vivo Glutathione, oxidized is reduced back to GSH via the NADPH-dependent enzyme glutathione reductase

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For controls, we used littermate wildtype mice, which underwent the same intracranial AAV injections

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have shown that DENV-2 infection alters oxidative stress by increasing the levels of malondialdehyde (MDA), the end product of lipid peroxidation, and the oxidized glutathione/GSH ratio 126